Tottenham are missing both Harry Kane and Heung-min Son to injury.
Wolves continue their push for European qualification with a win over Norwich City. They are just two points off of fifth-placed Manchester United before the weekend games.
Spurs have suffered defeats to Leipzig and Chelsea.
Mourinho mentioned that his side are missing a number of key players, including a striker.
Wolves have taken points off of Manchester United and Leicester City, along with Norwich.
Tottenham team news
Ryan Sessegnon is with a muscular injury.
Long-term absentees Harry Kane, Heung-min Son, Juan Foyth and Moussa Sissoko remain sidelined.
Wolves team news
Jonny Castro Otto is Wolves’ only injury concern for Sunday.
The Spaniard suffered an ankle injury against Norwich and is unlikely to feature against Spurs.