Gameweek 2 gives us with Liverpool getting things underway against Burnley in the early Saturday kick-off.
There are four 5pm games as champions Manchester City look to recover from their opening defeat to Tottenham with a home tie against Norwich.
Aston Villa host Newcastle after both sides lost their first matches, Crystal Palace take on Brentford after the Bees’ famous win over Arsenal, and Leeds take on Everton in what could be an enthralling encounter. Brighton and Watford then finish off the action at the Amex Stadium in the evening.
Spurs head to Wolves, while Sunday’s late game is a London derby between Arsenal and Chelsea at the Emirates.
We will also have the first Monday night clash as West Ham entertain Leicester City.
Premier League 2021/22 fixtures, gameweek 2
Saturday 21 August
2.30 | Liverpool vs Burnley
5.00 | Aston Villa vs Newcastle
5.00 | Crystal Palace vs Brentford
5.00 | Leeds vs Everton
5.00 | Man City vs Norwich
7.30 | Brighton vs Watford
Sunday 22 August
4.00 | Southampton vs Manchester United
4.00 | Wolves vs Tottenham
6.30 | Arsenal vs Chelsea
Monday 23 August
10.00 | West Ham vs Leicester