Manchester City and Manchester United go head to head at the Etihad Stadium.
The Red Devils, who start the weekend second in the EPL table with a 14 point adrift off Pep Guardiola’s side.
Liverpool are back to their losing ways after their Thursday night game at Anfield, after another defeat to Chelsea, this time against Fulham.
Thomas Tuchel’s Blues made it into the Premier League’s top four.
West Ham host Leeds at the London Stadium.
Elsewhere on Sunday, Tottenham are at home to Crystal Palace as the EPL’s late kick off.
West Brom and Newcastle struggling on together at the Hawthorns.
Arsenal are up for an early kick off at Turf Moor, as they tackle Sean Dyche’s Burnley.
The Foxes go to Brighton, who are missing several key players of their own.
Sheffield United and Southampton complete the Premier League set on Saturday afternoon at Bramall Lane.
Premier League fixtures for matchweek 27, schedule and EAT match times
Saturday, March 6
Burnley vs Arsenal – 3:30 PM EAT
Sheffield United vs Southampton – 6:00 PM EAT
Aston Villa vs Wolverhampton – 8:30 PM EAT
Brighton vs Leicester City – 11:00 EAT
Sunday, March 7
West Brom vs Newcastle United – 3:00 PM EAT
Liverpool vs Fulham – 5:00 PM EAT
Manchester City vs Manchester United – 7:30 PM EAT
Tottenham vs Crystal Palace – 10:15 PM EAT
Monday, March 8
Chelsea vs Everton – 9:30 PM EAT
West Ham vs Leeds – 11:00 PM EAT