Cologne were last edged 2-1 by Rhine Derby rivals Borussia Mönchengladbach but Markus Gisdol’s men had won each of their previous three games to open up a 14-point gap on the automatic relegation places.
Robin Zentner was ruled out for the rest of the season after suffering a cruciate ligament injury in his knee.
Cologne: Horn – Ehizibue, Bornauw, Leistner, Katterbach – Skhiri, Hector (c) – Kainz, Uth, Drexler – Cordoba
Mainz: Müller – St. Juste, Bruma, Niakhate – Baku, Barreiro, Latza (c), Mwene – Onisiwo, Quaison – Szalai
- Cologne would be fourth in the standings having won five of their last six Bundesliga home games, only losing to Bayern Munich.
- Mainz have lost all eight games this season in which they have conceded the first goal.